Tom and Greg are enslaved in Mr Smithson's coal mine. Elsewhere, the Family are desperately tracking Billy, their only lead, across the country. At a roadside motel Billy stops to meet his girlfriend Sally and when the Family confront him, Billy claims ignorance. Meanwhile in the mine, Greg formulates an escape plan, convincing Smithson that he's discovered a gas leak. However the Family are converging on Smithson's as well with their own rescue plans, leading to a game of cat and mouse.

Trapped in the body of her father's prototype Cylon soldier, Zoe Graystone attempts to adjust to her new life. Meanwhile, Amanda learns of her daughter's secrets

Victor is forced to go back out into the real world when his contract as an active lapses, but his past life could threaten his plans with Sierra.

Two brothers travel through America hunting demons. Sam, Dean and Bobby must deal with the aftermath of the devil's escape from hell.

Sam, Dean and Bobby find themselves out of their depth when an investigation proves more than they bargained for.

Kate finds herself on the run, and Jack is tasked with something that could endanger a friend's life...

Melinda is drawn to a man suffering from amnesia and must find a way to help him recover his memory

Sylar continues to torment Matt. HRG and Tracy help a young boy who has suffered many hardships in his life. Claire and Gretchen have a problem with their new sorority sisters hazing them.